Looking for image processing filter/techinque for Lung anomalies in CT scan

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I am doing a research in medical images, mainly CT scan Lung Nodules images. I've found other techniques from various papers. Rolling Ball algorithm for smoothing the image is one of them. Anti-aliasing Threshold can be also easily achieved using the Curve function. However, I am curious whether are there other GIMP plugins or techniques out there that can suit my need?

I am looking for image processing filter/technique to enhance the lung image in some ways so that lung's anomalies such as nodules or cancer can be easier to detect by a machine learning program. If possible, please suggest all image processing techniques for this case. 

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